Genomes of higher eukaryotes contain abundant non‐coding repeated sequences whose overall biological impact is unclear. They comprise two categories. The first consists of retrotransposon‐derived elements. These are three major families of retroelements (LINEs, SINEs and LTRs). SINEs are clustered in gene‐rich regions and are found in promoters of genes while LINEs are concentrated in gene‐poor regions and are depleted from promoters. The second class consists of non‐coding tandem repeats (satellite DNAs and TTAGGG arrays), which are associated with mammalian centromeres, heterochromatin (...) and telomeres. Terminal TTAGGG arrays are involved in telomere capping and satellite DNAs are located in heterochromatin, which is implicated in transcription silencing by gene repositioning (relocalization). It is unknown whether interstitial TTAGGG sequences, which are present in many vertebrates, have a function. Here, evidence will be presented that retroelements and TTAGGG arrays are involved in regulation of gene expression. Retroelements can provide binding sites for transcription factors and protect promoter CpG islands from repressive chromatin modifications, and may be also involved in nuclear compartmentalization of transcriptionally active and inactive domains. Interstitial telomere‐like sequences can form dynamically maintained three‐dimensional nuclear networks of transcriptionally inactive domains, which may be involved in transcription silencing like classic heterochromatin. BioEssays 30:338–348, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

First published in English in 1935, this is a vital and stimulating critical appraisal of contemporary thought in the post-World War One era. Written by a selection of leading Marxist thinkers including Nikolai Bukharin, who would later become one of the most famous victims of Stalin's show trials, this work offers a Marxist critique of contemporary thought relating to philosophy, science and history. The authors all lean towards the view that the general tendency of modern thought is to abandon (...) the historical method and to deny progress, with the conclusion that Marxism was the only historical and progressive outlook in science, philosophy and history in the period following the First World War and the Communist revolution in Russia. A fascinating document of great historical and political interest which offers an invaluable insight into contemporary thought in the Soviet Union of the 1930s. (shrink)

Responding to recent concerns about the reliability of the published literature in psychology and other disciplines, we formed the X-Phi Replicability Project to estimate the reproducibility of experimental philosophy. Drawing on a representative sample of 40 x-phi studies published between 2003 and 2015, we enlisted 20 research teams across 8 countries to conduct a high-quality replication of each study in order to compare the results to the original published findings. We found that x-phi studies – as represented in our sample (...) – successfully replicated about 70% of the time. We discuss possible reasons for this relatively high replication rate in the field of experimental philosophy and offer suggestions for best research practices going forward. (shrink)

Appendix 1 was incomplete in the initial online publication. The original article has been corrected.

Znachenie gegelevskoĭ filosofii v nastoi︠a︡shchee vremi︠a︡. 1860.--Feĭerbakh. 1864.--Glavnai︠a︡ cherta myshlenii︠a︡. 1866.--Klod Bernar o metodi︠e︡. opytiv. 1867.--Kuzen. 1867.--Bekon. 1867.--Angliĭskai︠a︡ psikhologii︠a︡. 1867.--Iz sporov o dushi︠e︡. 1870.--Beneke. 1872.--O chisto-ėmpiricheskom metodi︠e︡. 1872.--T︠S︡eller. 1873.--Millʹ v svoeĭ avtobiografii. 1874.--Gartman i SHopengauėr. 1875.--SHopengauėr. 1881.--O zadachakh istorii filosofii. 1893.--Razbory knig. 1873-1891.

t. 2. Choveshkata spet︠s︡ifika -- t. 3. Choveshkata pamet.

The article explores the concept of "conscience" in three language pictures of the world - Russian, French and Chinese. The study is contrastive, the results obtained are compared. The description of each concept is made according to a clear algorithm: the etymology of the word, the mythological roots of the concept, its compatibility are studied, the material connotation is singled out from the compatibility according to V. A. Uspensky, dictionary definitions are compared. The purpose of the study is to identify (...) the features of the representation of the concept of "conscience" in different cultures using the material of the semantic field in Russian, French and Chinese, then making a comparison in order to see similarities and differences in the worldview picture of different peoples. This topic is understudied, earlier there were no linguoculturological studies analyzing Russian, French and Chinese cultures, which is the scientific novelty of this work. As a result, a clear difference in the ideas of conscience in the three studied cultures was established. For a Russian person, conscience is an internal judge who punishes him when he commits an evil deed; for the French, conscience has no connection with power over a person, and even often yields to it; for the Chinese, conscience is a guide that a person can follow or deny. The results obtained will contribute to the establishment of mutual understanding between cultures, forming a kind of conceptual bridge. (shrink)

The author examines the idea of "mind" in three linguistic pictures of the world - Russian, French and Chinese. The study is contrastive, the results are compared. The description of each idea is made according to a clear algorithm: the etymology of the word, the mythological roots of the concept, its compatibility, from the compatibility is distinguished real connotation according to V. A. Uspensky, a comparison of dictionary definitions is made. The aim of the study is to identify the peculiarities (...) of the idea of "mind" in the Russian, French and Chinese languages. The purpose of the comparison is to see the similarities and differences in the worldview of different peoples. Scientific methods of research are: comparative-historical method, method of generalization, method of semantic analysis. This topic is understudied, no linguocultural studies analyzing this idea in Russian, French and Chinese culture have been observed earlier, which constitutes the scientific novelty of the work. The results will contribute to mutual understanding between peoples, forming a kind of conceptual bridge, and will also be used in courses on regional studies, comparative studies of cultures, and in the teaching of the respective languages. (shrink)

Filosofii︠a︡ svobodnogo dukha : problematika i apologii︠a︡ khristianstva (p. 13-[228]) -- I︠A︡ i mir obʹektov : opyt filosofii odinochestva i obshchenii︠a︡ -- Sudʹba cheloveka v sovremennom mire : k ponimanii︠u︡ nasheĭ ėpokhi -- Dukh i realʹnostʹ : osnovy bogochelovecheskoĭ dukhovnosti.

1. Samopoznanie -- 2. Smysl tvorchestva -- 3. Tipy religioznoĭ mysli v Rossii -- 4. Dukhovnye osnovy russkoĭ revoli︠u︡t︠s︡ii ; Filosofii︠a︡ neravenstva.

Nikolai Alekseevich Umov , a professor at Moscow and New Russian universities, Russia's first theoretical physicist and a mathematical philosopher, according to N. E. Zhukovskii's definition, developed a genuinely ecological philosophy, which is usually included in the philosophy of Russian cosmism. He made the first global forecast1 that took into account the finiteness of resources on earth, population growth, and food reserves.